Driving Productivity, Expanding Capability
Over the last month we have added to the capabilities of Reach Separations. We have been fortunate to procure some new Preparative Chromatography equipment which will help us to increase our resources significantly.
We are now able to run systems in parallel which has given the ability to either work faster or to purify larger amounts of material. This has already led to two large chiral batches being purified. Both batches were in the range of 50g and because of our increased system capability delivery projects were comfortably inside the schedule of the client's requirements.
The increase in our capabilities and resources now enables us to run four or five projects simultaneously and is allowing us to complete purification projects quickly to meet client needs and demand.
One of our Gilson Preparative HPLC systems now has the capability to collect into large vessels rather than individual tubes. By incorporating a high-pressure switching valve into our existing Gilson preparative hardware we now have the capability, due to some innovative method creation, to collect individual enantiomers from multiple 'stacked' injections into 2 large volume collection vessels. This offers significant advantages.
For example, the programmatically controlled valve switches ensure there is no chance of the wrong enantiomer ever being combined with the bulk of the other enantiomer - an issue which exists, due to inevitable human error, when combining a large number of smaller fraction tubes by hand. Equally, the restrictions in production purification are reduced by switching to large volume collection vessels. The use of fraction cubes limits the number of injections per sequence based on the number of tube locations available. By removing this enforced limitation the time a sequence of production injections can operate for is only based on the volumes of mobile phase solvent that are considered safe to have in one location.
Performance in Chiral Purification
One of our key strengths is in Chiral Chromatography. With our column diversity, techniques and instrument manipulation and lean protocols we are able to be thorough and rapid in our determinations to find a method of separation. Our primary toolbox of conditions involves 98 different separation technique/stationary phase/mobile phase connotations. Furthermore, secondary and tertiary screens pushes this up to 132 different experiments.
The Normal Phase screen is 10 columns 3 solvent conditions. This takes 12.5 hours.
Polar Organic is 6 columns 4 solvent conditions. This takes 10 hours.
Reversed Phase is 5 columns 1 solvent condition. This takes 2.5 hours.
SFC is 13 columns 3 solvent conditions. This takes 5.2 hours.
To find out more about how we can help you with your chiral purification requirements,
a member of the team today.