88 Ways to Screen a Chiral Compound - September 2017
The bottle neck in a busy purification laboratory quite often is not the purification itself, but finding the right method. Chiral screening used to mean lots of waiting and probably (at Reach, definitely!) lots of coffee, as each column was equilibrated and each method ran. It could easily take 30-.....
Developing an achiral SFC screen - 8th February 2016
Here at Reach Separations we are not ones to shy away from promoting the benefits of SFC. Both the time and energy savings during post processing and evaporation, and the reduction in organic solvents used, make SFC a greener technique than traditional normal phase methods.
However, we admit that w.....
Coming to the end of my Placement - July 2015
I am coming to the end of my 12 month industrial placement at Reach Separations, and I wanted to share some of my reflections on how the year has progressed. Earlier in my placement, I wrote a piece about why I chose to work at Reach and beginning my project. I definitely pushed myself out of my com.....
Optimising Manufacturer Injection Protocol - 21th November 2014
A recent addition to the laboratory here at Reach Separations is an Aurora Fusion SFC. Another analytical system that we hope to put into use to speed up screening, both for chiral and achiral separations. However, not being ones to accept straight off the shelf equipment, or out of the manual metho.....
A day in the life of a chiral sample. - 12th September 2014
A day in the life of a chiral sample - 12th September 2014
In any given week Reach Separations can get up to 20 samples entering the lab. The life of a sample here at Reach is a short but interesting one. This is the story of a standard sample for chiral purification as it passes through one of ou.....
Are Small and Medium Enterprises (SMEs) the way forward when applying for internships? - 16th July 2014
I am currently undertaking a summer internship at an SME within the chemical industry called Reach Separations and before I submitted my application I hadn’t even heard of them. Whilst browsing through their twitter feed I came across a very thought-provoking article written by a biochemist and sc.....
Application time - 13th June 2014
There seems to a plethora of people sharing advice via various social media channels recently on how to secure that perfect position. Some of it I agree with, some of it seems ineffective but not detrimental to an application and some tips, if followed, would make me move the application to the reje.....
Improving Communication - 29th January 2014
As an internal service provider communication with your customers is easy. If they are not in the same lab as you, there is a good chance they are in the same building. A brief stroll and you can have a 2 minute chat about any issues that might have cropped up with the purification of their sample.
Achiral SFC – In at the deep end! - 30th October 2013
Using SFC for chiral separations is a no brainer, but until recently we hadn't really thought about the practicalities of using SFC for achiral purification.
The benefits of SFC chiral chromatography: fewer salt issues, reduced solvent, faster dry down, higher throughput, faster .....
Does Social Media Really Work?? - 01st October 2013
Everyone has heard about it and almost everyone knows how to use it. However the question is, 'Can social media be used to promote a small science based business like Reach Separations?'
Of course, like with every marketing technique, there are pros and cons but with numbers like 10 million Linke.....
Tri, Tri and Tri Again. - 22nd September 2013
Reach Separations were represented by no fewer than 4 people at the Southall Sprint Triathlon this weekend.
MD Duncan Cliff, Technical Director Phil Abbott and Senior Separations Scientists Alex Brien and Victoria Coulthard all got up at an ungodly hour on the Sunday morning, all in the name of t.....
A Month Goes So Quickly - 16th September 2013
My summer placement here at Reach separations has now come to a rapid end with the usual flourish of last minute activity to try and get as much done as possible.
I was really dropped in at the deep end in the first couple of weeks working with Alex on a highly complex separation trying to isolat.....
The Super Part of SFC - 1st August 2013
We all know that HPLC and SFC both have their place in chiral and now achiral purification. We all know that SFC, when appropriate can be quicker, cheaper and more efficient. However some examples can show this at its extreme.
A four component sample arrived in the lab. A customer.....
REACHing New Heights!! - 9th July 2013
This weekend saw the second challenge of the summer. After last week’s achievement on the bike we took on the National Three Peak Challenge...
The clock was started early Saturday evening at Nevis, 5.28pm and a gentle climb across the fields in relatively nice (it is Scotland!) weather. We soo.....
New SFC - 'Super Fast Cycling' - 03rd July 2013
Friday the 21st of June 6PM and the scene was set for what we believed was going to be a pleasant cycle around the Embankment in Nottingham as the four strong team of Alex Brien (Reach Separations), Michael Cooke (Sygnature Discovery), Carlos Fernadez-Lence (Pharminox) and Simon Goddard (Renasci) to.....
Crossing Borders - 13th May 2013
Within the scientific community there is always a strong flow of ‘word of mouth’. Throughout the 16 months in business Reach Separations has benefitted from this form of extremely effective marketing. From the comments that have eventually returned to us through our network its clear we have .....
Minimising Manual Handling - Always Beneficial - 1st May 2013
We all know what it is, we all know how easy it is to make a mistake, we all know how time consuming it is and we all know the dangers of dealing with fraction tubes. So the obvious question is how can you minimize manual handling?
Now, some pieces of equipment are designed to collect into larger.....
Identical Systems - Double The Fun - 18th April 2013
There is always a fine balancing act in any purification business between the amount instrumentation required to do the job and the amount of instrumentation you would like. Having hardware sitting around idle is a cost to the business. Whereas not having enough instrumentation causes increased turn.....
The Cost of 'Right First Time' Purification - 12th February 2013
With the cost of designing, producing, and delivering a drug to market ever increasing, it essential for businesses to reduce costs by any means necessary. Sadly, it appears some only see the easy option of making 100s of talented scientists redundant. Our industry is downsizing. But it is these exp.....
Always Better To Go One Step Further - 13th November 2012
It has been acknowledge that enantiomers of drug substances produce significantly different pharmacokinetic and pharmacological activities. For this reason finding an efficient way of separating them has become an important aspect in the drug discovery process.
It is often considered that an a.....
Maximising Speed and Efficiency in Purification - 16th October 2012
The title of this blog is pretty self-explanatory. Everyone wants to do purification quicker and slicker. Sometimes you are forced into it due to workload and other times it is an inventive idea. In this blog we will detail the benefits of using stacked injections in chiral chromato.....
The politics of evaluation. - 20th September 2012
About 15 years ago, whilst working at the bench as a synthetic chemist in a big pharma company I was asked to evaluate a 'new' column technology. Within the chemistry department I was considered a 'superuser' of the then, shiny and new, Agilent 1100 stack so this didn't strike me as too strange, des.....
Benefits of Using HPLC for Reaction Monitoring for University Labs - July 2012
Background - A third-year undergraduate chemistry project which involves the synthesis of mixtures of two dipeptide derivatives (4/6 and 5/7). At the moment 1H NMR is relied upon to determine the isomeric ratio, but a robust, fast, quantitative HPLC method is required so that this .....
Why Flexibility and Communication are the key to customer satisfaction. Chiral Screening and Purification. - May 2012
The definition of flexibility is 'being responsive to change' or 'susceptible to influence,' and communication is 'the exchange of information or news'. For any company but especially an outsource company it is essential to be flexible to meet customer requirements. It is also important to keep the .....
Pharma and CRO's - April 2012
Why Outsource Purification Can Benefit Both Large Pharma and CRO's
Isolation and purification techniques play a massive role in drug discovery. Being able to strategically control your synthetic route is vital. In recent years both High Performance Liquid Chromatography (HPLC.....